Iron chelating agents for iron overload diseases
نویسندگان
چکیده
منابع مشابه
Using Iron-Chelating Agents in Critically Ill Patients with Iron Overload. Fact or Fiction?
Recently, some evidence has shown that the failure of iron homeostasis may occur in critically ill patients and can lead to iron overload. Elevated ferritin levels as a body iron burden index in critically ill patients may be associated with depressed level of consciousness and greater mortality. However, the necessity of using iron-chelating agents in clinical situation is still unknown for th...
متن کاملManagement of transfusional iron overload – differential properties and efficacy of iron chelating agents
Regular red cell transfusion therapy ameliorates disease-related morbidity and can be lifesaving in patients with various hematological disorders. Transfusion therapy, however, causes progressive iron loading, which, if untreated, results in endocrinopathies, cardiac arrhythmias and congestive heart failure, hepatic fibrosis, and premature death. Iron chelation therapy is used to prevent iron l...
متن کاملIron chelating agents for treating malaria.
BACKGROUND Researchers are exploring the effects of adding treatments to the main antimalarial regimens in an attempt to reduce mortality from Plasmodium falciparum. Iron chelation is one potential chemotherapeutic adjuvant treatment. Before advocating adjunctive therapy, the effects of iron chelators in improving patient outcomes need to be examined. OBJECTIVES To assess the effects of iron-...
متن کاملSynthetic chelating agents in iron metabolism.
Iron in man is held within the cells incorporated in organic complex molecules, either as functional iron, i.e., hemoglobin and tissue enzymes, or as storage iron, i.e., ferritin and hemosiderin. Owing to the requirements of the erythroid marrow in particular, large amounts of iron must constantly pass from one cell to another through the plasma. This plasma transport is brought about by a #3gl...
متن کاملThe Effect of Combination Iron Chelating Agents on Reducing the Severity Grading of Heart and Liver Iron Overload in β-Thalassemia Patients
Background: Deferasirox (DFX), Deferoxamine (DFO), and Deferiprone (DFP) are iron chelators that can be used in thalassemic patients with iron overload. Materials and Methods: This clinical trial was performed on 108 thalassemic patients who were randomly divided into group A (n=54) and B (n=54). Group A received combination of DFX and DFP, and group B received DFO and DFP for six months. Seru...
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ژورنال
عنوان ژورنال: Thalassemia Reports
سال: 2014
ISSN: 2039-4365,2039-4357
DOI: 10.4081/thal.2014.s1.2046